ParkinsonCanadaV1, Main, Exploration, bibRecord, 003577

Monoclonal antibodies against Epstein-Barr virus cross-react with α-synuclein in human brain

Identifieur interne : 003577 ( Main/Exploration ); précédent : 003576; suivant : 003578

Monoclonal antibodies against Epstein-Barr virus cross-react with α-synuclein in human brain

Auteurs : J. Woulfe [Canada] ; H. Hoogendoorn [Canada] ; M. Tarnopolsky [Canada] ; D. G. Munoz [Canada, Espagne]

Source :

Neurology [ 0028-3878 ] ; 2000.

RBID : Pascal:01-0010818

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Virus Epstein Barr, Anticorps monoclonal, Immunohistochimie, Réaction croisée, Etude cas, Exploration, Homme, Synucléine-α.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Antibodies, Monoclonal (immunology), Brain (pathology), Case study, Cross reaction, Enzyme-Linked Immunosorbent Assay, Epstein Barr virus, Exploration, Herpesvirus 4, Human (immunology), Human, Humans, Immunoblotting, Immunohistochemistry, Lewy Body Disease (pathology), Monoclonal antibody, Nerve Tissue Proteins (immunology), Parkinson Disease (immunology), Parkinson Disease (pathology), Parkinson disease, Synucleins, alpha-Synuclein.
MESH :
- chemical , immunology : Antibodies, Monoclonal, Nerve Tissue Proteins.
- immunology : Herpesvirus 4, Human, Parkinson Disease.
- pathology : Brain, Lewy Body Disease, Parkinson Disease.
- Enzyme-Linked Immunosorbent Assay, Humans, Immunoblotting, Immunohistochemistry, Synucleins, alpha-Synuclein.

Abstract

Article abstract-Using antibodies generated against the latent membrane protein 1 of Epstein-Barr virus, intense immunoreactivity of Lewy bodies (in PD and dementia with Lewy bodies) and glial cytoplasmic inclusions (in multiple system atrophy) was demonstrated. ELISA and Western blotting techniques confirmed that this immunolabeling was due to cross-reactivity of the antiviral antibody with α-synuclein, a neuronal protein implicated in the pathogenesis of PD. This example of cross-reactivity between Epstein-Barr virus and α-synuclein may bear implications for further elucidating infectious or autoimmune mechanisms in PD.

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">Article abstract-Using antibodies generated against the latent membrane protein 1 of Epstein-Barr virus, intense immunoreactivity of Lewy bodies (in PD and dementia with Lewy bodies) and glial cytoplasmic inclusions (in multiple system atrophy) was demonstrated. ELISA and Western blotting techniques confirmed that this immunolabeling was due to cross-reactivity of the antiviral antibody with α-synuclein, a neuronal protein implicated in the pathogenesis of PD. This example of cross-reactivity between Epstein-Barr virus and α-synuclein may bear implications for further elucidating infectious or autoimmune mechanisms in PD.</div>
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La maladie de Parkinson au Canada (serveur d'exploration)

Monoclonal antibodies against Epstein-Barr virus cross-react with α-synuclein in human brain

Monoclonal antibodies against Epstein-Barr virus cross-react with α-synuclein in human brain

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	La maladie de Parkinson au Canada (serveur d'exploration)
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